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[Emerging Microbes & Infections] Genomic characterization of COVID-19 isolated from a patient who visited Wuhan

Emerging Microbes & Infections, 28 Jan 2020

Jasper Fuk-Woo Chan, Kin-Hang Kok, Zheng Zhu, Hin Chu, Kelvin Kai-Wang To, Shuofeng Yuan & Kwok-Yung Yuen

Betacoronavirus genome organization.

Highlights

  • Bioinformatics analysis on a virus genome from a patient with COVID-19 infection and comparison with other related coronavirus genomes.
  • The genome of COVID-19 has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV
  • Learning from the roles of civet in SARS and camel in MERS, hunting for the animal source of COVID-19 and its more ancestral virus would be important for understanding the origin and evolution of this novel lineage B betacoronavirus.
  • Findings provide the basis for starting further studies on the pathogenesis and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection.

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香港01:袁國勇:港大成功「種病毒」 可即時測試抗病毒方法

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