The Journal of Infectious Diseases, 21 June 2020
Dong Yang, Hin Chu, Yuxin Hou, Yue Chai, Huiping Shuai, Andrew Chak-Yiu Lee, Xi Zhang, Yixin Wang, Bingjie Hu, Xiner Huang, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Jie Zhou, Shuofeng Yuan, Anna Jinxia Zhang, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
- Monocyte-derived dendritic cells (moDCs) and macrophages (MDMs) were permissive to SARS-CoV-2 infection and protein expression but did not support productive virus replication.
- SARS-CoV-2 launched an attenuated interferon response in both cell types.
- SARS-CoV-2 triggered significant pro-inflammatory cytokine/chemokine expression in MDMs but not in moDCs.
- These findings on pathogenesis may explain the mild and insidious course of COVID-19 till late deterioration.