[Cell Reports Medicine] Oral SARS-CoV-2 inoculation establishes subclinical respiratory infection with virus shedding in golden Syrian hamsters

05/10/2020

Cell Reports Medicine, 21 September 2020

Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Jasper Fuk-Woo Chan, Can Li, Zhimeng Fan, Feifei Liu, Yanxia Chen, Ronghui Liang, Siddharth Sridhar, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kelvin Kai-Wang To, Shuofeng Yuan, Jie Zhou, Hin Chu, Kwok-Yung Yuen

Graphical abstract from the research paper

Highlights

Oral inoculation of SARS-CoV-2 can establish respiratory infection in hamsters
Orally infected hamsters do not have bodyweight loss and sign of disease
Orally infected hamsters have a lower viral load and milder inflammation in lung
Orally and intranasally infected hamsters have comparable level of virus shedding

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