[Cell Reports] Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

Cell Reports, 17 May 2020
Huibin Lv, Nicholas C. Wu, Owen Tak-Yin Tsang, Meng Yuan, Ranawaka A.P. M. Perera, Wai Shing Leung,Ray T.Y. So, Jacky Man Chun Chan, Garrick K. Yip, Thomas Shiu Hong Chik, Yiquan Wang, Chris Yau Chung Choi, Yihan Lin, Wilson W. Ng, Jincun Zhao, Leo L.M. Poon, J. S. Malik Peiris, Ian A. Wilson, Chris K.P. Mok

Graphical Abstract of the cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections


  • Explores the antigenic differences between SARS-CoV-2 and SARS-CoV by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV
  • While cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses may be rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike

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