[Nature Immunology] ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection

Nature Immunology, 17 August 2020

Hachim, A., Kavian, N., Cohen, C.A. et al.


  • Utilized the luciferase immunoprecipitation system to assess the antibody responses to 15 different SARS-CoV-2 antigens in patients with COVID-19.
  • Identified new targets of the immune response to SARS-CoV-2 and show that nucleocapsid, open reading frame (ORF)8 and ORF3b elicit the strongest specific antibody responses.
  • ORF8 and ORF3b antibodies, taken together as a cluster of points, identified 96.5% of COVID-19 samples at early and late time points of disease with 99.5% specificity.

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