[Science Advances] Viruses harness YxxØ motif to interact with host AP2M1 for replication: a vulnerable broad-spectrum antiviral target

Science Advances, 14 August 2020

Yuan, S.F., Chu, H., Huang, J.J. & et al.

Highlights:

• Discovered a common YxxØ-motif of multiple viruses that exploits host AP2M1 for intracellular trafficking.
• N-(p-Amylcinnamoyl)anthranilic acid (ACA) was identified to interrupt AP2M1-virus interaction and exhibit potent antiviral efficacy against a number of viruses in vitro and in vivo
• YxxØ mutation, AP2M1 depletion or disruption by ACA causes incorrect localization of viral proteins, which is exemplified by the failure of nuclear import of IAV nucleoprotein as well as diminished endoplasmic reticulum localization of ZIKV-NS3 and enterovirus-A71-2C proteins, thereby suppressing viral replication

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